Sant'Onofrio al Gianicolo is a titular church in Trastevere, Rome. It is the official church of the papal order of knighthood Order of the Holy Sepulchre. A side chapel is dedicated to the Order and a former grand master, Nicola Canali is entombed there. It is dedicated to Saint Onuphrius and located on the Janiculum.
It was built in 1439 on the site of an ancient hermitage, as part of a cloistered monastery of the Hieronymites that existed here from the 15th-16th century. The attached cloister was added in the mid-15th century.
A member of the College of Cardinals is sometimes given title to the church, that is, designated cardinal deacon or cardinal priest of Sanr'Onofrio. The last to hold the title was Cardinal Carlo Furno from 1994 to 2015.
