Palazzo Sacchetti is a palazzo in Rome, important for historical and artistic reasons.
The building was designed and owned by Antonio da Sangallo the Younger and completed by Nanni di Baccio Bigio or his son Annibale Lippi. After Sangallo, the palace belonged among others to the Ricci, Ceoli and Sacchetti, important families of the Roman nobility. Among the artworks that decorate the interior, the cycle of frescoes depicting the Storie di David by Francesco Salviati represents an important work of Mannerism. The palace also housed hundreds of paintings that would become the nucleus of the Pinacoteca Capitolina. Palazzo Sacchetti is widely considered the most important palace in Via Giulia.